A study done to evaluate the usefulness of changes in a non- invasive parameter called End Tidal Carbon Dioxide after giving fluid infusion to neurosurgery patients to predict whether they will respond with an increase in cardiac output

Not yet recruiting

• Conditions: Other specified disorders of central nervous system,

• Registration Number: CTRI/2024/01/061105
• Lead Sponsor: Dr. Anjali R Hegde

Brief Summary

This is a prospective observational study to evaluate the utility of change in end tidal carbon dioxide after volume expansion using 4 ml per kg of crystalloid solution in predicting fluid responsiveness in patients undergoing neurosurgery in supine position under general anaesthesia. Optimum intra-operative fluid management is essential in neurosurgery patients to balance risk of cerebral ischemia versus cerebral edema. Fluid responsiveness can be used to identify patients on the ascending portion of Frank – Starling curve, who can increase cardiac output in response to volume expansion. EtCO2 depends on three variables – Tissue CO2 production, pulmonary blood flow (i.e. cardiac output), and alveolar ventilation. Hence when CO2 production and ventilatory  parameters are kept constant, EtCO2 may accurately indicate cardiac output. With this study we plan to evaluate usefulness of EtCO2, a simple, inexpensive, non -invasive parameter, to predict fluid responsiveness in operation theatre.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-01-01
• Study Start: 2024-01-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1.ASA I & II patients 2.Patients aged above 18years 3.Patients undergoing neurosurgery in supine position under general anaesthesia.

Exclusion Criteria

• Patients with cardiac arrhythmias, valvular heart diseases or left or right heart failure 2.
• Patients with chronic obstructive pulmonary disease with a MMRC Dyspnea Scale 3 or more 3.
• Patients with intrathoracic lesions 4.
• Pregnant women 5.
• Patients on vasoactive drugs.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in End tidal carbon dioxide after volume expansion to predict fluid responsiveness defined as fall in Pleth Variability Index to less than 14 percent and increase in SBP by 10 mm Hg or more	Baseline, 1 min, 3 min, 5 mins and 10 mins after completion of infusion.

Secondary Outcome Measures

Name	Time	Method
Pleth Variability Index and Pulse Pressure Variation	Baseline, 1 min, 3 min, 5 mins and 10 mins after completion of infusion.

Trial Locations

Locations (2)

Pradhan Mantri Swasthya Suraksha Yojana Hospital; 🇮🇳 Bangalore, KARNATAKA, India

Victoria Hospital; 🇮🇳 Bangalore, KARNATAKA, India

Pradhan Mantri Swasthya Suraksha Yojana Hospital

🇮🇳Bangalore, KARNATAKA, India

Dr Surekha C

Principal investigator

9845489724

suri.c13@gmail.com