The effect of oral probiotic(LactoCare) on psoriasis patients

Phase 2

• Conditions: Psoriasis.; Psoriasis vulgaris; L40.0

• Registration Number: IRCT20221213056802N1
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 March 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Age of 18 to 65 years
Signing the informed consent form
Patients with the diagnosis of the moderate to severe psoriasis based on Psoriasis Area and Severity Index( PASI score)

Exclusion Criteria

Pregnant or lactation
Suffering from other autoimmune disease and inflammation disease
Suffering from cirrhosis and hepatic disease
Suffering from metabolic syndrome
Suffering from severe renal disease
The consumption of antibiotics and any kind of probiotics 2 weeks ago
Worsening of signs and symptoms of psoriasis during treatment

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The population of TH1. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH2. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of Treg. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of B cells. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.;The population of TH17. Timepoint: 3 months later the consumption of oral probiotics. Method of measurement: Flowcytometry.