The effect of oral ingestion of probiotics on the frequency and intensity of migraine attacks

Completed

• Conditions: cephalagia; Headache; 10019231

• Registration Number: NL-OMON35284
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Frequency of at least 4 migraine attacks (or days) per month
- Pattern of migraine attacks predictable/stable (frequency, duration, intensity)
- Preferably: migraine patients with self-reported gastrointestinal complaints (before, during or after their migraine attacks), such as diarrhoea, bloating, or constipation.

Exclusion Criteria

- chronic daily migraine
- medication-dependent headaches
- cluster headache or tension-type headaches
- antibiotics use up to two months before the start of the treatment period
- probiotics use up to two weeks before the start of the treatment period
- Female migraine patients who are pregnant or lactating (the migraine pattern is influenced).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Incidence and severity of migraine attacks, measured by headache diaries</p><br>

Secondary Outcome Measures

Name	Time	Method
<p> The disability due to migraine attacks is measured by validated headache<br /><br>questionnaires (MIDAS and HDI questionnaire).</p><br>