Effect of Probiotic Nata Jelly from Pineapple Juice on Depressive, Anxiety and Stress Symptoms

Phase 1

Completed

• Conditions: Probiotic; Nata Jelly; Pineapple; Depression; Anxiety; Stress; Healthy condition

• Registration Number: TCTR20221123005
• Lead Sponsor: ational Research Council of Thailand (NRCT)

Brief Summary

This study indicate that Probiotic Nata Jelly from Pineapple Juice show increase working memory and reduction of oxidative stress, which still needs further study.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-23
• Study Completion: 2023-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

1. Healthy volunteers aged between 30-65 years old who live in Northeastern of Thailand.
2. Volunteers don't have menopause syndromes.
3. All volunteers don't have serious physical illnesses such as diabetes, high blood pressure, heart disease, liver disease, kidney disease, lung disease or allergies, and mental disorders.
4. All volunteers don't get medicine or hormone or other medicines that affect the nervous system and bone during the trial and within three months before the start of the test.
5. All volunteers don't smoke more than 10 pieces per day
6. All volunteers don't have an alcohol addiction
7. On the study day, all volunteers felt well and refrain from drinking tea, coffee, or alcohol at least 12 hours.

Exclusion Criteria

1. Volunteers who have been diagnosed with one of the following; cardiovascular diseases, respiratory diseases, neurological diseases, psychiatric disorders, head injury, diabetes mellitus, liver disease, cancer, autoimmune disease, hematological disorder, and gout or high uric acid.
2. Volunteers who were exposed to pesticides during one week before the test.
3. Volunteers who have been Hysterectomy and/or Oophorectomy.
4. Volunteers who require supplements or any drug that effect on the nervous system by order of the doctor during the trial.
5. Volunteers who participate in other projects.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depressive, Anxiety and Stress Symptoms 8 weeks Depression Anxiety Stress Scale 21 Thai (DASS-21 Thai)

Secondary Outcome Measures

Name	Time	Method
Positive mood evaluation 8 weeks MOSAIC questionnaire,Sleep quality 8 weeks Pittsburgh Sleep Quality Index - Thai (PSQI- Thai),The changes of oxidative stress status 8 weeks Laboratory,The changes of 5-hydroxytryptamine (5-HT) and melatonin 8 weeks ELISA Kit,Serum cortisol 8 weeks Laboratory,Working memory test 8 weeks Computerized cognitive batteries test ,The changes of hematological and clinical chemistry parameters 8 weeks Laboratory