The effect of probiotic supplementation on cognitive function in Alzheimer's patients

Phase 3

Conditions: Alzheimer disease.
Alzheimer's disease

Registration Number: IRCT20210513051277N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 30

Inclusion Criteria

Age 80-50 years
Resident of Tehran
Diagnosis of Alzheimer's disease according to NINCDS-ARDA criteria maximum in the last 2 years
BMI=18/5-30 Kg/m2
Use of acetylcholinesterase inhibitors (AchEIs) and N-methyl dispartate (NMDA) receptor antagonists
caregivers understands the objectives of the study and agrees to follow the necessary rules throughout the study

Exclusion Criteria

Having frontotemporal dementia, Levy Buddy dementia, Parkinson's disease dementia and any type of severe dementia
Take antibiotics at least three months before enrollment
Smoking (at least 5 cigarettes a day for the past 6 months) and other tobacco (pipe and hookah at least once a month
Any drug addiction
Follow a specific diet for three months before the study
People who participated in another study less than two months ago.
Take any amount of supplements or foods fortified with fins or probiotics during the last 3 months
History of serious kidney, liver, intestinal, endocrine diseases, cardiovascular, gastrointestinal, pulmonary, blood and metabolic diseases, thyroid, rheumatoid arthritis and lupus
History of major gastrointestinal surgeries including gastrectomy, bowel restriction, etc.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function. Timepoint: Measurement of cognitive function at the beginning of the intervention (before the start of the intervention) and the end of week 12. Method of measurement: Mini–Mental State Examination questionnaire.

Secondary Outcome Measures