Effect of Probiotics supplementation on health statusamong liver disease patients waiting for liver transplantation â?? a randomized,double blind, controlled trial
Not Applicable
- Conditions
- Health Condition 1: - Health Condition 2: K746- Other and unspecified cirrhosis ofliver
- Registration Number
- CTRI/2021/07/034917
- Lead Sponsor
- Jawarhalal Institute of Postgraduate Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) Males and females aged >18 yrs with Liver cirrhosis of known etiology.
b)Active status on the waiting list
c) Provide informed consent
Exclusion Criteria
a) Pregnancy / under Fertility treatments
b)Malignancy except HCC
c)Human immunodeficiency virus infection
d)Creatinine clearance <50 mL/min
e)Cystic fibrosis
f)Consumption of probiotics in any form within one month prior to participation
â??g)Chronic gastrointestinal disorder including inflammatory bowel disease and celiac disease
â??h)Chronic immunosuppressive medication usage.
i)â??Liver transplantation schedule within six weeks from the day of enrollment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the effect of probiotics on nutritional status,intestinal permeability and inflammatory markers in cirrhotic patients waiting for <br/ ><br>liver transplantation compared to placeboTimepoint: At baseline and after 6 weeks of probiotic supplementation
- Secondary Outcome Measures
Name Time Method To assess the effect of probiotics on liver disease severity in cirrhotic patients waiting <br/ ><br>for liver transplantation compared to placeboTimepoint: At baseline and after 6 weeks of probiotic supplementation