Enhancing Motor Learning with a Single Dose of Levodopa

• Conditions: revalidatie na herseninfarct/bloeding; n.a.

• Registration Number: NL-OMON46724
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 42

Inclusion Criteria

Healthy
Male
Aged 18-55 years
Informed consent obtained

Exclusion Criteria

History of neurological or psychiatric disorders
History of neurosurgery
History of Sleep disorders
History or evidence of renal, gastrointestinal, hepatic or hematologic abnormalities
Using acute or chronic psychoactive drugs
Alcoholism
Smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main objective of the study is to determine the role of dopamine on motor<br /><br>learning in healthy individuals. The participants will be subjected to two<br /><br>different cerebellar specific motor adaptation paradigms: the inward saccade<br /><br>adaptation task and the visuomotor adaptation task. The motor learning capacity<br /><br>will be determined by quantifying the velocity and gain of adaptation. The<br /><br>motor timing, motor tremor, motor strength and attention task are control<br /><br>experiments that allow us to put the output parameters of adaptation tasks in<br /><br>the correct perspective. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>