Is MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins? - measurement of AGD / 2D:4D ratio

Completed

Conditions: Mayer Rokitanski Kuster Hauser syndrome
10038608
10010612

Registration Number: NL-OMON48729

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 172

Inclusion Criteria

MRKH group (43 patients)
- Diagnosed with MRKH syndrome
- Age * 18 years
- signed informed consent ;PCOS group:(43 patients)
- Diagnosed with PCOS
- Age * 18 years
- signed informed consent ;endometriosis group: (43 patients)
- Diagnosed with moderate-severe endometriosis
- Age * 18 years
- signed informed consent ;Control group: (43 patients)
- Age * 18 years
- Regular, ovulatory cycle
- ICSI treatment for male infertility
- signed informed consent

Exclusion Criteria

MRKH women
- not willing to participate in the study
PCOS group:
- vaginal delivery in the medical history
- diagnosed with endometriosis
- not willing or able to sign the informed consent;Endometriosis group:
- vaginal delivery in the medical history
- diagnosed with PCOS
- not willing or able to sign the informed consent;Control group:
- diagnosed with PCOS/endometriosis
- ICSI treatment after a total fertilization failure in IVF cycle
- vaginal delivery in the medical history
- not willing or able to sign the informed consent

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study outcome is the AGDac in all 4 groups. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study outcomes are:<br /><br>- the difference in AGDaf and 2D:4D ratio in the four different patient groups<br /><br>(MRKH vs. PCOS vs. endometriosis vs. controls)<br /><br><br /><br>The following parameters will also be monitored: age, ethnicity, BMI, medical<br /><br>history, signs of clinical hyperandrogenism (by questionnaire) and ovarian<br /><br>morphology by ultrasound.</p><br>