Distribution of Pulmonary Ventilation in Lateral Decubitus of Healthy Adults Under Non-Invasive Mechanical Ventilation

Not Applicable

Completed

• Conditions: Patient Positioning; Noninvasive Ventilation
• Interventions: Device: Positive End Expiratory Pressure 5 H2O; Device: Positive End Expiratory Pressure 10 H2O

• Registration Number: NCT06489509
• Lead Sponsor: Attikon Hospital

Brief Summary

The aim was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects.

Detailed Description

In lateral decubitus, the largest percentage of pulmonary ventilation of non-sedated subjects is distributed mainly in the dependent lung. The aim It was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects. The volunteers were noninvasively ventilated in both lateral positions and supine positions at the beginning and end of the process. It is concluded that implementing Non-Invasive Ventilation in the lateral body position resulted in increased ventilation of the dependent lung. In contrast, the respective ventilation of the non-dependent lung was further decreased.

Study Timeline

• Study Start: 2017-12-06
• Primary Completion: 2018-07-08
• Study Completion: 2018-07-08
• Study First Submitted: 2024-06-26
• Status Verified: 2024-07
• Study First Submitted QC: 2024-07-03
• Last Update Submitted: 2024-07-07
• Study First Posted: 2024-07-08
• Last Update Posted: 2024-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Healthy Volunteers

Exclusion Criteria

• Chronic respiratory disease
• BMI>40
• Smoking history

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Left position	Positive End Expiratory Pressure 5 H2O	Left lateral decubitus
Right position	Positive End Expiratory Pressure 10 H2O	Right lateral decubitus
Supine position	Positive End Expiratory Pressure 10 H2O	Supine experimental position
Left position	Positive End Expiratory Pressure 10 H2O	Left lateral decubitus
Supine position	Positive End Expiratory Pressure 5 H2O	Supine experimental position
Right position	Positive End Expiratory Pressure 5 H2O	Right lateral decubitus

Primary Outcome Measures

Name	Time	Method
The percentage change in pulmonary ventilation	Up to 3 minutes	The percentage change in pulmonary ventilation was measured at each position, without applying external positive end-expiratory pressure and under positive end-expiratory pressure of 5 and 10 cmH2O

Trial Locations

Locations (2)

Attikon University Hospital; 🇬🇷 Athens, Attica, Greece

Grigoriadis Konstantinos; 🇬🇷 Athens, Attica, Greece