Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS
Not Applicable
Recruiting
- Conditions
- ARDS: Acute Respiratory Distress Syndrome
- Registration Number
- NCT06696638
- Lead Sponsor
- XiaoJing Zou,MD
- Brief Summary
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- Diagnosed with ARDS according to the 2023 global new definition of ARDS.
- Age ≥ 18 years.
Exclusion Criteria
- Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
- Pulmonary interstitial disease.
- Uncorrected shock of various types.
- Intracranial hypertension.
- Pregnant and postpartum women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT 1 Hour Post-Intervention
- Secondary Outcome Measures
Name Time Method Global inhomogeneity assessed by electrical impedance tomography 1 Hour Post-Intervention Center of ventilation assessed by electrical impedance tomography 1 Hour Post-Intervention ventilation/perfusion matching assessed by EIT 1 Hour Post-Intervention Respiratory system compliance 1 Hour Post-Intervention Tidal volume divided by plateau pressure
mean arterial pressure 1 Hour Post-Intervention
Trial Locations
- Locations (1)
Wuhan Union hospital
🇨🇳Wuhan, Hubei, China