Electrical Impedance Tomography in Guiding Early and Precise Rehabilitation of Patients with Difficult Ventilator Weaning

Not Applicable

Not yet recruiting

• Conditions: Difficult-to-Wean Patients

• Registration Number: NCT06677099
• Lead Sponsor: Capital Medical University

Brief Summary

Diaphragm dysfunction, ineffective chest wall and respiratory muscle function are frequently observed in critically ill patients with difficult weaning from mechanical ventilation(MV).It is the leading cause of retention of airway secretions and insufficient airway clearance.Thechest physiotherapy (CPT) of critically ill patients can reduce secretion retention. We designed a protocol to investigate the feasibility and efficacy of CPT guided by electrical impedance tomography (EIT) in Difficult-to-Wean patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2024-11-05
• Study First Submitted QC: 2024-11-05
• Last Update Submitted: 2024-11-05
• Study First Posted: 2024-11-06
• Last Update Posted: 2024-11-06
• Study Start: 2024-11-07
• Primary Completion: 2025-11-30
• Study Completion: 2025-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• mechanical ventilation patients who are ≥18 years old, are received to invasive mechanical ventilation more than 96 hours before randomization, are meted the preconditions for the machine to be withdrawn, and at least have one failed attempt to withdraw the ventilator (re-need ventilator support within 48 hours after extubation),
• willing to participate in the study and sign the informed consentsent.

Exclusion Criteria

• Malignant arrhythmia or acute myocardial ischemia
• Pneumothorax, pulmonary bulla and barotrauma and other lung diseases
• Hemorrhagic disease or abnormal coagulation mechanism with bleeding tendency
• Chest skin trauma
• Pulmonary hypertension and pulmonary embolism
• With a permanent or temporary pacemaker
• There is malignant tumor
• Present and previous history of neuromuscular diseases affecting respiratory muscle
• Participated in another clinical study related to mechanical ventilation withdrawal
• Can not cooperate with the study for any reason or the researcher thinks that it is not suitable to be included in this experiment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
peak expiratory flow	All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3)

Secondary Outcome Measures

Name	Time	Method
The cumulative incidence of successful weaning by Day 30	from admission to discharge, assessed up to 1 day
Maximum inspiratory pressure	All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3)
Diaphragm thickening rate	All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3)
Diaphragmatic excursion	All data will be recorded at the baseline (T1), 14 days (T2) and 28 days (T3)
Length of ICU stay	from admission to discharge, assessed up to 1 day
Cumulative incidence for death before successful weaning	from admission to discharge, assessed up to 1 day