Measurement of lung function after surfactant administratio

Not Applicable

• Conditions: Prematurity; Surfactant deficiency; Respiratory - Other respiratory disorders / diseases; Respiratory - Normal development and function of the respiratory system; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12620000337976
• Lead Sponsor: Mater Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-03-10
• Last Update Posted: 16 March 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

•Infants 26 0/7 to 31 6/7 weeks corrected gestational age (gestation at birth plus days since birth)
•Weight appropriate for gestational age at birth
•Age < 72 hours
•Currently on nCPAP with an FiO2 requirement <0.30
•Approval of treating medical and nursing staff for recruitment to relevant study arm
•Parent(s) or guardian able and willing to provide informed consent
•At least one parent or guardian aged 18 years or older at the time of consent
•Have not yet received a dose of surfactant

Exclusion Criteria

•Apgar score less than or equal to 5 at five minutes after birth
•Both parents of baby under 18 years of age (due to the complexities of obtaining consent).
•Prior instillation of surfactant
•Congenital anomaly or syndrome expected to have significant effect on cardio-respiratory function
•Other diseases interfering with cardiopulmonary functions (hydrops fetalis, toxoplasmosis, rubella, cytomegalovirus, herpes simplex)
•Known or suspected chromosomal abnormality
•Concomitant or expected treatment with inhaled nitric oxide
•Any infant with fragile skin where EIT belt placement or TBS placement may damage the skin.

Study & Design

• Study Type: Interventional
• Study Design: Not specified