Genetic variants of sex hormone receptors in patients with atrial fibrillation - GENE-AF

Klinikum Bielefeld Mitte0 个研究点目标入组 40 人开始时间: 2024年1月31日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Patients with atrial fibrillation (ICD-10 code: I48.0 or I48.1) > 18 years of age
•- Postmenopausal status in women (last menstrual period > 12 months ago). Premenopausal women would experience excessive hormonal fluctuations due to their menstrual cycle.
•- Ability to give consent and sufficient knowledge of German

•- Obesity = size II (BMI = 35kg/m2)
•- Manifest hyperthyroidism (TSH < 0.25 µIU/ml)
•- Harmful alcohol use according to ICD10/WHO definition
•- The following valve conditions: mitral valve stenosis, moderate/high-grade aortic valve stenosis, moderate/high-grade mitral valve insufficiency
•- Postoperative status (operation < 10 d)
•- Sepsis according to WHO definition
•- Acute or chronic infections (CRP > 15 mg/dl)
•- Indications of CHD (corresponding symptoms, echocardiographic or ECG morphological abnormalities) or already diagnosed CHD
•- Hypokalemia (K+ < 3.0 mmol/l)
•- Acute or chronic right heart strain (systolic pulmonary artery pressure (sPAP) = 36 mmHg in transthoracic echocardiography) (e.g. pulmonary artery embolism or COPD)
•- Obstructive sleep apnea syndrome (OSAS)
•- Chronic renal insufficiency
•- (uncontrolled) arterial hypertension
•- (Z.n.) malignant gynecological tumor disease, (Z.n.) prostate carcinoma, (Z.n.) hormonally active tumors
•- Z.n. ovariectomy or Z.n. orchiectomy
•- Hormone metabolism disorders with an influence on sex hormone levels
•- Daily intake of NSAIDs (diclofenac, ASA, naproxen or ibuprofen),
•- Intake of opiates or cortisone compounds
•- Hormonal therapy
•- Non-consenting ability

发起方

Klinikum Bielefeld Mitte