Evaluation of effect of addition of magnesium sulphate to bupivacaine for spinal anaesthesia in pregnant women

Completed

• Conditions: ASA I/II parturients

• Registration Number: CTRI/2015/05/005749
• Lead Sponsor: Lady Hardinge Medical College

Brief Summary

The aim of our study was to evaluate whether addition of magnesium sulphate to intrathecal hyperbaric bupivacaine has any effect on prolonging the duration of postoperative analgesia as compared to hyperbaric bupivacaine alone, in patients undergoing lower segment Caesarean section. Also to compare the onset & duration of sensory and motor blockade, neonatal outcome and side-effects, in the two groups. 

We found that magnesium sulphate (50mg) as an adjuvant to hyperbaric bupivacaine intrathecally produces a significant prolongation in the duration of postoperative analgesia in patients undergoing lower segment Caesarean section.. It produces a sensory block of significantlylonger duration as compared to hyperbaric 0.5% bupivacaine alone ; but a prolongation in the duration of motor block whichis seen with magnesium sulphate is not desirable as it delays the earlymobilisation of patients.  However,magnesium sulphate as an adjuvant to bupivacaine maybe beneficial in stableeclamptic patients or patients in whom side-effects related to intrathecalopioids aren’t desirable in prolonging the duration of post-operativeanalgesia. The incidence of hypotension andbradycardia were also comparable between the two groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03-11
• Last Update Posted: 2015-04-28

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

ASA I and II parturients Undergoing lower segment Caesarean section.

Exclusion Criteria

patient refusal any contraindication to regional anaesthesia weight>90kg height<145 or >170cm known allergy to local anaesthetic or magnesium sulphate dysrrthymias in ECG or any systemic disorder history of chronic pain already on magnesium therapy severe psychiatric disturbance history of drug abuse unable to communicate in either hindi or english.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prolongation in duration of postoperative analgesia with addition of intrathecal magnesium sulphate to hyperbaric bupivacaine as compared to hyperbaric bupivacaine with normal saline	time interval between administration of intrathecal block and first request for analgesia by patient(visual analog score more than 4 ) was noted

Secondary Outcome Measures

Name	Time	Method
Onset of sensory & motor block was slower while duration of sensory as well as motor block was prolonged with magnesium sulphate group. Neonatal APGAR scores and incidence of side-effects were comparable in the two groups	Continuous ECG,HR,SpO2 were monitored. Non-invasive BP,PR & level of sedation at every 3min interval till delivery of baby,thereafter at 5min interval till end of surgey,postop at 30min interval for first 2hr then hourly till first recue analgesic

Trial Locations

Locations (1)

lady hardinge medical college, new delhi; 🇮🇳 Delhi, DELHI, India

lady hardinge medical college, new delhi

🇮🇳Delhi, DELHI, India

SUSHMITA ROY

Principal investigator

7838553257

mita.sush17@gmail.com