Targeting of treatment of the patent ductus arteriosus using early echocardiography

Not Applicable

Completed

• Conditions: Patent ductus arteriosus; Cardiovascular - Normal development and function of the cardiovascular system

• Registration Number: ACTRN12608000295347
• Lead Sponsor: Martin Kluckow

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-06-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 370

Inclusion Criteria

Infants born < 29 weeks gestational age
Infants < 12 hours old
Echocardiogram to assess ductal size able to be performed

Exclusion Criteria

1] Intraventricular haemorrhage grade 3 – 4 at time of initial scan.
2] Baby is clinically unstable and not expected to survive.
3] Congenital anomalies predicted to influence neurodevelopmental outcome
4] Structural heart disease
5] R->L shunt - infants with near systemic or suprasystemic pulmonary pressure who may benefit from some RV pressure relief – R>L ductal flow for >33% of cardiac cycle. Rescan in same 12 hour time frame.
6] Contraindication to use of indomethacin or ibuprofen (Platelet count <50,000, Creatinine >120 micromol/L, use of NSAID antenatally)
7] Unlikely to be able to commence first dose of treatment by 12 hours of age
8] Consent not given

Study & Design

• Study Type: Interventional
• Study Design: Not specified