The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal

Not Applicable

Completed

• Conditions: Endothelial Dysfunction
• Interventions: Other: Orange Juice; Other: Red Wine; Other: Water; Other: Green Tea

• Registration Number: NCT03806829
• Lead Sponsor: University of the Highlands and Islands

Brief Summary

High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.

Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-06
• Primary Completion: 2018-07-31
• Study Completion: 2018-07-31
• Status Verified: 2019-01
• Study First Submitted: 2019-01-14
• Study First Submitted QC: 2019-01-14
• Last Update Submitted: 2019-01-14
• Study First Posted: 2019-01-16
• Last Update Posted: 2019-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Females to be postmenopausal and not on hormone replacement therapy
• 25 > BMI < 35
• Sedentary to light activity lifestyle.

Exclusion Criteria

• History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
• History of diabetes (Type 1 or type 2)
• Vegan or with food allergies or intolerances.
• Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
• Taking prescription medication for hypertension.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Orange Juice + Meal	Orange Juice	250 ml Orange Juice and a high calorie, high fat meal (\>900 kcal, 50g fat)
Red Wine + Meal	Red Wine	250 ml Red Wine and a high calorie, high fat meal (\>900 kcal, 50g fat)
Water + Meal	Water	250 ml Water and a high calorie, high fat meal (\>900 kcal, 50g fat)
Green Tea + Meal	Green Tea	250 ml Green Tea and a high calorie, high fat meal (\>900 kcal, 50g fat)

Primary Outcome Measures

Name	Time	Method
Endothelial (dys)function	2 hours post-prandial	Assessed via flow mediated dilatation

Secondary Outcome Measures

Name	Time	Method
Plasma antioxidant capacity	2 hours post-prandial	Plasma oxygen radical absorbance capacity
Plasma ox-LDL	2 hours post-prandial
Plasma Nitrite	2 hours post-prandial

Trial Locations

Locations (1)

University of the Highlands and Islands; 🇬🇧 Inverness, United Kingdom