Effects of high-protein and high-fat oral preloads on thermogenesis, apetite perceptions and energy intake, and the relationship with gastrointestinal motility, gastric emptying and gut hormone release, in overweight men.

Not Applicable

Completed

• Conditions: Obesity; Diet and Nutrition - Obesity

• Registration Number: ACTRN12611000941965
• Lead Sponsor: Professor Christine Feinle-Bisset

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 16

Inclusion Criteria

16 overweight/obese (BMI 27-35kg/m2) subjects will be recruited. All subjects will be required to be weight-stable (i.e. <5% fluctuation in their body weight) at study entry. Subjects will be requried to maintain their normal physical activity over the course of the study.

Exclusion Criteria

Significant gastrointestinal symptoms, disease or surgery, use pf prescription or non-prescription medications (including vitamins and herbal suppliments) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg. domperidone and cisapride, anticholinergic drugs (ag. atropine), metoclopramide, erythromycin, hyoscine, orlistat, geren tea extracts, Astragalus, St Johns Wort etc), intolerance /allergy to paracetamol, current gallbladder or pancreatic disease, diabetes mellitus, epilepsy, cardiovascular or respiratory disease, any other illness as assessed by the investigator (including chronic illnesses not explicitly listed above), high performance athletes, current intake of >2 standard drinks on >5 days per week, curent smokers of cigarettes/cigars/marijuana, current intake of any illicit substances, restrained eaters (score > 12 on the three factor eating questionnaire), experience claustrophobis in confined spaces, or unable to comprehend the study protocol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thermogenesis[Thermogenesis will be determined by indirect calorimetry using a clear plastic ventilated hood and the TrueOne metabolic monitor for 40 minutes from 0800h and then for 3 hrs after the consumption of the experimental preload.];Macronutrient and total energy intake at the buffet meal.[The buffet meal will be presented at t=180 minutes, and the subject will be allowed to freely consume food until confortably full for 30 minutes until t=210. Macronutrient and total energy intake will be analysed using the FoodWorks software program.]

Secondary Outcome Measures

Name	Time	Method
Antropyloroduodenal motility[Using a manometri assembly and catheter, Antropyloroduodenal pressures will be continously monitored after the consumption of the preload from t=-15 until t=180 min.]