Pilot Study: The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 7
- Locations
- 2
- Primary Endpoint
- Endothelial (dys)function
Study Overview
Brief Summary
High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.
Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Females to be postmenopausal and not on hormone replacement therapy
- •25 > BMI < 35
- •Sedentary to light activity lifestyle.
Exclusion Criteria
- •History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
- •History of diabetes (Type 1 or type 2)
- •Vegan or with food allergies or intolerances.
- •Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
- •Taking prescription medication for hypertension.
Arms & Interventions
Red Wine + Meal
250 ml Red Wine and a high calorie, high fat meal (>900 kcal, 50g fat)
Intervention: Red Wine (Other)
Orange Juice + Meal
250 ml Orange Juice and a high calorie, high fat meal (>900 kcal, 50g fat)
Intervention: Orange Juice (Other)
Water + Meal
250 ml Water and a high calorie, high fat meal (>900 kcal, 50g fat)
Intervention: Water (Other)
Green Tea + Meal
250 ml Green Tea and a high calorie, high fat meal (>900 kcal, 50g fat)
Intervention: Green Tea (Other)
Outcomes
Primary Outcomes
Endothelial (dys)function
Time Frame: 2 hours post-prandial
Assessed via flow mediated dilatation
Secondary Outcomes
- Plasma antioxidant capacity(2 hours post-prandial)
- Plasma ox-LDL(2 hours post-prandial)
- Plasma Nitrite(2 hours post-prandial)