The Acute Effects of Commercially Available Drinks on the Endothelial Function of Humans Following a High-fat Meal
- Conditions
- Endothelial Dysfunction
- Registration Number
- NCT03806829
- Lead Sponsor
- University of the Highlands and Islands
- Brief Summary
High fat diets are associated with impaired endothelial function and increased cardiovascular disease risk amongst our population. These negative effects are likely caused by triglyceride induced suppression of nitric oxide, which is produced from the endothelium, and/or an increase in oxidative stress.
Interestingly, previous studies have found that some beverages that are high in polyphenols and antioxidants may suppress the impairment in endothelial function observed following high fat meals/diets. Typically, these studies have investigated the ingestion of red wine, orange juice or green tea on outcome measures (typically flow mediated dilatation (FMD) of the brachial artery). Despite this previous research, no study has compared the effects of different beverages on endothelial outcomes following a high-fat meal within the same participants.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
- Females to be postmenopausal and not on hormone replacement therapy
- 25 > BMI < 35
- Sedentary to light activity lifestyle.
- History of cardiovascular disease (Hypertension, Atherosclerosis, endothelial issues etc).
- History of diabetes (Type 1 or type 2)
- Vegan or with food allergies or intolerances.
- Taking any antioxidants over the counter (Vit C, E or polyphenol supplements)
- Taking prescription medication for hypertension.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Endothelial (dys)function 2 hours post-prandial Assessed via flow mediated dilatation
- Secondary Outcome Measures
Name Time Method Plasma ox-LDL 2 hours post-prandial Plasma Nitrite 2 hours post-prandial Plasma antioxidant capacity 2 hours post-prandial Plasma oxygen radical absorbance capacity
Trial Locations
- Locations (1)
University of the Highlands and Islands
🇬🇧Inverness, United Kingdom
University of the Highlands and Islands🇬🇧Inverness, United Kingdom