Ultrasound in the Intensive Care Unit and Measurable Indicators of Systemic Inflammation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Inflammation Process
- Sponsor
- Osijek University Hospital
- Enrollment
- 61
- Locations
- 1
- Primary Endpoint
- Brachial artery flow velocity - 1
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.
Detailed Description
The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel \[dB\] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults over 18 years of age
- •Postoperative surgical patients
- •Signed informed consent
Exclusion Criteria
- •Refusal to give informed consent
- •A previous thromboembolic event of the brachial artery
- •Acute infection of the upper extremity
Outcomes
Primary Outcomes
Brachial artery flow velocity - 1
Time Frame: within 4 hours of admission to ICU.
measurement of a brachial artery flow velocity \[cm/s\] at admission.
White blood cell count - 2
Time Frame: day 2 after admission is between 24 and 48 hours after admission.
blood sample analysis for white blood cell count (WBC \[10\^9/L\]) on day 2 after admission.
Procalcitonin - 2
Time Frame: Day 2 after admission is between 24 and 48 hours after admission.
Blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) on day 2 after admission.
Diameter of brachial artery - 1
Time Frame: within 4 hours of admission.
Measurement of a brachial artery diameter \[cm\] at admission. Admission day is considered as day 1.
Distance from skin to third metacarpal bone - 2
Time Frame: day 2 after admission is between 24 and 48 hours after admission.
measurement of a distance from the skin to third metacarpal bone (cm) on day 2 after admission.
C-reactive protein - 2
Time Frame: day 2 after admission is between 24 and 48 hours after admission.
Blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration on day 2 after admission.
Procalcitonin - 1
Time Frame: within 4 hours of admission.
blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) at admission.
Diameter of brachial artery - 2
Time Frame: day 2 after admission is between 24 and 48 hours after admission.
measurement of a brachial artery diameter \[cm\] on day 2 after admission.
Brachial artery flow velocity - 2
Time Frame: day 2 after admission is between 24 and 48 hours after admission.
measurement of a brachial artery flow velocity \[cm/s\] on day 2 after admission. Day 2 is Measurement of a brachial artery flow velocity \[cm/s\] between 24 and 48 h after ICU admission.
Distance from skin to third metacarpal bone -1
Time Frame: within 4 hours of admission.
measurement of a distance from the skin to third metacarpal bone (cm) at admission.
C-reactive protein - 1
Time Frame: within 4 hours of admission.
blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration at admission.
White blood cell count - 1
Time Frame: within 4 hours of admission.
blood sample analysis for white blood cell count (WBC \[10\^9/L\]) at admission.