Ultrasound in the Intensive Care Unit and Measurable Indicators of Systemic Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Brachial artery flow velocity - 1
研究概览
简要总结
The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.
详细描述
The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel [dB] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults over 18 years of age
- •Postoperative surgical patients
- •Signed informed consent
排除标准
- •Refusal to give informed consent
- •A previous thromboembolic event of the brachial artery
- •Acute infection of the upper extremity
结局指标
主要结局
Brachial artery flow velocity - 1
时间窗: within 4 hours of admission to ICU.
measurement of a brachial artery flow velocity \[cm/s\] at admission.
White blood cell count - 2
时间窗: day 2 after admission is between 24 and 48 hours after admission.
blood sample analysis for white blood cell count (WBC \[10\^9/L\]) on day 2 after admission.
Procalcitonin - 2
时间窗: Day 2 after admission is between 24 and 48 hours after admission.
Blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) on day 2 after admission.
Diameter of brachial artery - 1
时间窗: within 4 hours of admission.
Measurement of a brachial artery diameter \[cm\] at admission. Admission day is considered as day 1.
Distance from skin to third metacarpal bone - 2
时间窗: day 2 after admission is between 24 and 48 hours after admission.
measurement of a distance from the skin to third metacarpal bone (cm) on day 2 after admission.
C-reactive protein - 2
时间窗: day 2 after admission is between 24 and 48 hours after admission.
Blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration on day 2 after admission.
Procalcitonin - 1
时间窗: within 4 hours of admission.
blood sample analysis for Procalcitonin concentration (PCT \[ug/L\]) at admission.
Diameter of brachial artery - 2
时间窗: day 2 after admission is between 24 and 48 hours after admission.
measurement of a brachial artery diameter \[cm\] on day 2 after admission.
Brachial artery flow velocity - 2
时间窗: day 2 after admission is between 24 and 48 hours after admission.
measurement of a brachial artery flow velocity \[cm/s\] on day 2 after admission. Day 2 is Measurement of a brachial artery flow velocity \[cm/s\] between 24 and 48 h after ICU admission.
Distance from skin to third metacarpal bone -1
时间窗: within 4 hours of admission.
measurement of a distance from the skin to third metacarpal bone (cm) at admission.
C-reactive protein - 1
时间窗: within 4 hours of admission.
blood sample analysis for C-reactive protein (CRP \[mg/L\]) concentration at admission.
White blood cell count - 1
时间窗: within 4 hours of admission.
blood sample analysis for white blood cell count (WBC \[10\^9/L\]) at admission.
次要结局
未报告次要终点