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Clinical Trials/NCT04173741
NCT04173741
Completed
Not Applicable

A Correlation Study in the Intensive Care Unit Between the Respiratory Variation Ratios of Internal Jugular Vein and Inferior Vena Cava Before and After Passive Leg Raise

Hacettepe University1 site in 1 country46 target enrollmentJanuary 5, 2018
ConditionsCritically Ill

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Critically Ill
Sponsor
Hacettepe University
Enrollment
46
Locations
1
Primary Endpoint
Ultrasonography (USG) Measurements
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

Intravascular volume assesment is important for the management of the patients in the intensive care unit. Respiratory variation ratio of the inferior vena cava (IVC) can be determined by ultrasonography (USG) and is a useful tool for hemodynamic evaluation of the patient.

Aim of this study is to search for correlation between respiratory variation ratios of the internal jugular vein (IJV) and the IVC before and after passive leg raise. Another aim of this study is to search for variability between ultrasonographic measurements of different doctors.

Detailed Description

The investigators measure the internal jugular vein (IJV) diameter in the short axis by using the linear probe (12-5 MHz) and M-mode of the ultrasound device in the junction of cricothyroid membrane level and midclavicular line. The inferior vena cava (IVC) is visualized in the subxiphoid long axis by using the convex probe (5-1 MHz). Diameter of the IVC is measured 2 cm caudally to the junction of the hepatic vein in M-mode. All measurements are done separately by 3 different doctors; one senior anesthesiology resident, one anesthesiology and critical care medicine fellow and one professor in anesthesiology and critical care. The first measurements of the IVC and the IJV are done in the supine position and the second ones are done after passive leg raise. Passive leg raise is done for 1 minute in the first group and for 3 minutes in the second group. Then distensibility (maximum diameter - minimum diameter / minimum diameter) and collapsibility (maximum diameter - minimum diameter / maximum diameter) indices are calculated. No fluid therapy or medication are given to the patients according to these measurements. Oxygen saturation, hearth rate and blood pressure levels are recorded before and after the measurements. The investigators also record age, gender, weight, height, body mass index, causes of admission, comorbidities, ventilator settings, vasoactive and diuretic medications, fluid intake and output volumes, Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sepsis-Related Organ Failure Assessment (SOFA) scores in the day of admission, Acute Physiology Score (APS) and SOFA scores in the day of measurement and length of stay in the intensive care unit. Patients with infection or surgical sutures in the site of measurement areas, intraabdominal hypertension, severe aortic regurgitation or lower extremity amputation history are excluded from the study.

Registry
clinicaltrials.gov
Start Date
January 5, 2018
End Date
December 1, 2019
Last Updated
5 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Asli Melek

Principal Investigator

Hacettepe University

Eligibility Criteria

Inclusion Criteria

  • Mechanically ventilated
  • Over 18 years of age

Exclusion Criteria

  • Infection in the site of measurement areas
  • Surgical sutures in the site of measurement areas
  • Intraabdominal hypertension
  • Severe aortic regurgitation
  • Lower extremity amputation

Outcomes

Primary Outcomes

Ultrasonography (USG) Measurements

Time Frame: through study completion, 3 days

Because of the medium-high interrater correlation between USG measurements of the physicians, statistical analysis were done with the mean of USG measurements of 3 doctors.

Study Sites (1)

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