Identifying Perceived Barriers and Facilitators to Inform the Development of a Liver Transplantation Prehabilitation Intervention
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 114
- Locations
- 1
- Primary Endpoint
- Liver frailty index (LFI) score
Study Overview
Brief Summary
The purpose of this study is to formally identify patient and caregiver perceived needs, barriers, and facilitators to inform the development of a home-based multimodal prehabilitation program for potential LT candidates.
Detailed Description
After being informed about the study and potential risks, all participants (patients and caregivers) giving written informed consent will be invited to participate in one of three research activities: interviews (n=10), nominal group technique meetings (n=64), or card-sorting and rating survey (n=40).
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 19 Years to 74 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Liver transplant (LT) candidates are:
- •Adult ESLD patients (age=19-74 years) who are assigned to the LT waitlist
- •English-speaking
- •No contraindication to moderate intensity physical activities
- •Physician clearance for participation in moderate intensity physical activities
- •No history of dementia or organic brain syndrome
- •Caregivers:
- •Adult (age≥ 19 years)
- •English-speaking
- •Provide direct care to LT candidates
Exclusion Criteria
- •Inability to communicate verbally in English
- •Documentation of cognitive deficits
Outcomes
Primary Outcomes
Liver frailty index (LFI) score
Time Frame: From baseline through 3 months
Change from baseline in liver frailty index score at 3 months; the higher LFI scores indicate a higher degree of frailty. LFI\<3.2: robust, LFI=3.2-4.4: prefrail, LFI\>=4.5: Frail.
Caregiver burden measured using Zarit Burden Interview short form (ZBI-12)
Time Frame: From baseline through 3 months
Change from baseline in the total ZBI-12 scores at 3 months. The total ZBI-12 score is the summation of 12 items, ranging from 0 to 48; the higher scores indicate higher burden (0-10:no to mild burden; 10-20: mild to moderate burden), and \>20: high burden.
Secondary Outcomes
No secondary outcomes reported
Investigators
Haiyan Qu
Associate Professor
University of Alabama at Birmingham