PD-1/PD-L1 Pathway Study on Septic Patients

Completed

• Conditions: Sepsis

• Registration Number: NCT01161745
• Lead Sponsor: Changhai Hospital

Brief Summary

The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.

Detailed Description

First, we will detect PD-L1 expression on PBMC of septic patients and healthy controls.

Second, blockade of PD-1/PD-L1 pathway in vitro and stimulate with some biomolecules and then analyze the PBMC function and apoptosis by flow cytometry.

Then, compare with healthy controls and find the differences.

Study Timeline

• Study Start: 2008-12
• Primary Completion: 2010-02
• Study Completion: 2010-04
• Status Verified: 2010-06
• Study First Submitted: 2010-07-13
• Study First Submitted QC: 2010-07-13
• Last Update Submitted: 2010-07-13
• Study First Posted: 2010-07-14
• Last Update Posted: 2010-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• patients who develop sepsis

Exclusion Criteria

• patients with cirrhosis or renal dysfunction
• patients with dyscrasia
• patients with autoimmunity diseases
• patients with severe cardiac and pulmonary diseases
• patients with hematological diseases
• patients with diabetes mellitus
• patients with malignant tumors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified