DIAPHRAGMATIC ULTRASOUND PARAMETERS TO PREDICT WEANING OUTCOME ON POST OPERATIVE MECHANICALLY VENTILATED PATIENTS

Not Applicable

• Conditions: Health Condition 1: B- Imaging

• Registration Number: CTRI/2023/06/053468
• Lead Sponsor: I

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

All patients in surgical intensive care unit who are above 18yrs on mechanical

ventilation through endotracheal tube or tracheostomy and eligible for weaning in accordance

with the following weaning criteria

Signs of reversal of the principal cause of mechanical ventilation

Accepted blood oxygenation i.e partial pressure of arterial oxygen (PaO2) equal to more

than 60mmHg, partial pressure of arterial carbon dioxide(PaCO2)equal to or less than

45mmHg , fraction of inspired oxygen (FiO2) equal to or less than 0.40, Positive end

expiratory pressure (PEEP) equal to or less than 5cmH2O and ratio of partial pressure of

arterial oxygen to the fraction of inspired oxygen equal to or more than 200

pH > 7.30; RR < 20 breaths/min , heart rate (HR) 60-100 /min , Rapid shallow breathing

index < 105 breaths /min/ml/kg bodyweight

Minimal use of inotropic or vasopressor drugs

Stable body hemodynamics

Adequate consciousness level

Does not receive sedatives or neuromuscular blocking agents

Analgesics needed for active pain are continued

No fever

Absence of hemorrhage or anemia with hemoglobin level > 7.5g/dl

No electrolyte disturbances

Exclusion Criteria

Patients <18 years old

ï?· Any patient with known neuromuscular disorder

ï?· Patients with known congenital lung or pleural malformation

ï?· Any patient with post esophageal or thorasic surgeries due to intra operative

diaphragmatic manipulation

Patients with restrictive lung diseases

Super obese patients

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome was the diagnostic accuracy of diaphragmatic ultrasound parameters for predicting weaning success. <br/ ><br>Successful weaning from mechanical ventilation was defined as the ability to tolerate spontaneous breathing for at least 48h without any level of assisted ventilation. <br/ ><br>Weaning failure was defined as the requirement for resumption of either invasive or noninvasive mechanical ventilation or reintubation within 48 hr after extubationTimepoint: 48 hours

Secondary Outcome Measures

Name	Time	Method
The secondary outcomes are the association between weaning parameters & diaphragmatic dysfunction & reintubation within 48 h after extubation.Timepoint: 48hours