Phenotypic and genetic characterization of circulating tumor cells and genetic characterization of the ctDNA and EV in patients with nonmetastatic gastroesophageal adenocarcinoma

Not Applicable

• Conditions: C15.9; C16.9; Oesophagus, unspecified; Stomach, unspecified

• Registration Number: DRKS00022197
• Lead Sponsor: Albert-Ludwigs-Universität Freiburg, Medizinische Fakultät-ausführende Stelle: Allgemein- und Vizeralchirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-25
• Study Completion: 2020-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

Ability to understand the content of the study and participate in the research.
Signed consent
> 18 years
Adenocarcinoma of the esophagus, esophagogastral junction or stomach cT1-cT4, Nx, M0
Planned neoadjuvant therapy (chemotherapy or chemoradiation)

Exclusion Criteria

Presence of another tumor
Chemotherapy or radiochemotherapy already received within the last 3 years.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification, morphological and immunophenotypic categorization of CTCs as well as genetic analysis of the CTC-DNA and investigation of the ctDNA and EV for mutations of known tumor-associated genes

Secondary Outcome Measures

Name	Time	Method
Description of the circulating tumor cells, ctDNA, EVs and the identified candidate mutations in connection with RFS and OS.