Genetics of aspirin resistance

Phase 4

Completed

• Conditions: Topic: Cardiovascular; Subtopic: Cardiovascular (all Subtopics); Disease: Cardiovascular; Circulatory System; Aspirin resistance

• Registration Number: ISRCTN06023644
• Lead Sponsor: Kings College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04-23
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Male or female aged 18 or more

Exclusion Criteria

1. Significant co-morbidity
2. Current regular therapy with any drug
3. Ingestion of aspirin, other non-steroidal anti-inflammatory drug, or other anti-platelet agent within the previous 30 days
4. Previous reaction to aspirin or other anti-platelet drug
5. History of dyspepsia or peptic ulceration
6. Pregnancy or female currently trying to conceive. Females of reproductive age wishing to take part will be asked to undergo a pregnancy test prior to inclusion, and will participate only if the test is negative.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of aspirin resistance at 1 month

Secondary Outcome Measures

Name	Time	Method
Presence/absence of genetic polymorphisms in a number of candidate genes possibly related to aspirin at 1 month