A study to improve our understanding of the genetic causes of swelling in babies before birth
Not Applicable
Completed
- Conditions
- Fetal oedema/hydrops with a focus on lymphatic related hydropsPregnancy and ChildbirthConditions involving the integument and temperature regulation of fetus and newborn
- Registration Number
- ISRCTN22076461
- Lead Sponsor
- St George’s University Hospitals NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. All cases of fetal hydrops at any gestation (as defined by the abnormal accumulation of fluid in two or more fetal compartments)
2. All cases of single compartment oedema (the abnormal accumulation of fluid within a fetal body cavity, for example, ascites, isolated hydrothoraces, generalised skin oedema)
3. Fetuses with a Nuchal Translucency (NT) >4.5mm at the 12/40 ultrasound scan.
4. Individuals affected by fetal oedema or hydrops in-utero for whom no explanation has been identified
Exclusion Criteria
Pregnancies with evidence of Rh or other blood group incompatibility (immune hydrops)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Part 1. Measurement of various indices from an ultrasound examination of affected pregnancy<br>Part 2. Information regarding fetal outcome/ child health and development, via a telephone interview with parents, at one year in children with a specific genotype<br>Part 3. Identification of sequence variants from genomic data sets
- Secondary Outcome Measures
Name Time Method