Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy Volunteers
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
This study has two main goals :
- to investigate the impact of aging on cortical excitability (CE)
- to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.
A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.
Investigators
Eligibility Criteria
Inclusion Criteria
- •male or female
- •age 18-75
- •signed informed consent
- •normal physical examination
Exclusion Criteria
- •less 18 or more 75 years of age
- •contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
- •severe physical disease
- •treatment with psychotropic drugs
- •overt psychiatric disease
- •alcohol consumption before the examination
Outcomes
Primary Outcomes
Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.
Time Frame: Participants will be followed for an expected average of one month
Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations. Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.
Durations of Cortical Silent Period (ms)
Time Frame: Participants will be followed for an expected average of one month
Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.