Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Device: TMS "Magpro®, Magventure Inc" device

• Registration Number: NCT02596789
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

This study has two main goals :

* to investigate the impact of aging on cortical excitability (CE)

* to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.

A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Study First Submitted: 2014-07-23
• Study First Submitted QC: 2015-11-03
• Study First Posted: 2015-11-04
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-03
• Last Update Posted: 2017-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• male or female
• age 18-75
• signed informed consent
• normal physical examination

Exclusion Criteria

• less 18 or more 75 years of age
• contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
• severe physical disease
• treatment with psychotropic drugs
• overt psychiatric disease
• alcohol consumption before the examination

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
state dependency TMS	TMS "Magpro®, Magventure Inc" device	TMS performed at rest and during a cognitive/emotional task

Primary Outcome Measures

Name	Time	Method
Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.	Participants will be followed for an expected average of one month	Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations.; Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.
Durations of Cortical Silent Period (ms)	Participants will be followed for an expected average of one month	Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.

Trial Locations

Locations (1)

Department of Psychiatry & Neurology - University Hospital Grenoble; 🇫🇷 Grenoble, France