Prospective, Single-blind Study Investigating the Effect of Sevoflurane and Desflurane, Agents Used in Patients on the MEP
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- Ear Deformities, Acquired
- Sponsor
- Trakya University
- Enrollment
- 50
- Primary Endpoint
- Middle ear pressure
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators aimed to examine the effect of sevoflurane and desflurane, agents used in patients who do not have any ear pathology and undergo surgery under general anesthesia, on the MEP.
Detailed Description
Studies reported that inhalation agents are more likely to have impacts on the middle ear pressure compared to intravenous anesthetic agents. Despite numerous studies comparing the effects of inhalation agents on the middle ear pressure, this is the first clinical trial in which end tidal carbon dioxide and effects of sevoflurane and desflurane, along with other anesthetic analgesic agents used, on the middle ear pressure were compared. Our purpose in this study was to investigate the effect of sevoflurane and desflurane, inhalation agents used in patients who do not have any ear pathology and undergo non-ear surgery under general anesthesia, on the middle ear pressure.
Investigators
Sevtap Hekimoglu Sahin
Clinical Professor
Trakya University
Eligibility Criteria
Inclusion Criteria
- •(ASA) II-III physical status
- •elective inguinal hernia
- •lower extremity surgery
- •general anesthesia
- •supine position
Exclusion Criteria
- •nasal septum,
- •adenotonsillar hypertrophy,
- •perforated tympanic membrane,
- •middle ear pathology
- •receive medications for middle ear pressure .
Arms & Interventions
sevoflurane 2%, 1 MAC
Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups.
Intervention: Sevoflurane
Desfluran 6-9% 1MAC
Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups.
Intervention: desflurane,
Outcomes
Primary Outcomes
Middle ear pressure
Time Frame: postoperative 30th minutes
Tympanometric measurements were performed and recorded for each ear preoperatively, at intraoperative 5th, 10th and 15th minutes and postoperative 10th and 30th minutes. Normal middle ear pressure ranges between -200 and +200 decapascals (daPa). Treatment-Related Adverse Events, Ear and labyrinth disorder Assessed by CTCAE v4.0