Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization
Overview
- Phase
- Phase 4
- Intervention
- sevoflurane and 0.5 μg/kg dexmedetomidine
- Conditions
- Intracranial Aneurysms
- Sponsor
- China Medical University, China
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Observing the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.
Investigators
Wen-fei Tan
Associate professor
China Medical University, China
Eligibility Criteria
Inclusion Criteria
- •18-65 years old ASA I or ASA II patients undergoing ECE treatment for intracranial aneurysms were included.
Exclusion Criteria
- •Patients were excluded based on the following parameters: older than 65 yrs, a history of mental illness, recent use of sedatives or analgesics and with sensation.
Arms & Interventions
sevoflurane and 0.5 μg/kg dexmedetomidine
After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes.
Intervention: sevoflurane and 0.5 μg/kg dexmedetomidine
sevoflurane and 1 μg/kg dexmedetomidine
After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes.
Intervention: sevoflurane and 1 μg/kg dexmedetomidine
Outcomes
Primary Outcomes
Observing the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.
Time Frame: At the end of the operation and 24 hours later
The time from termination of the general anesthetic to the time that the patient's eyes opened. Anesthesiologists collected information on emergence agitation, postoperative nausea and vomiting for 24 hours after the surgery.