The Effect of General Anesthesia on the Middle Ear Pressure
- Conditions
- Ear Deformities, Acquired
- Interventions
- Drug: desflurane,
- Registration Number
- NCT03100604
- Lead Sponsor
- Trakya University
- Brief Summary
The investigators aimed to examine the effect of sevoflurane and desflurane, agents used in patients who do not have any ear pathology and undergo surgery under general anesthesia, on the MEP.
- Detailed Description
Studies reported that inhalation agents are more likely to have impacts on the middle ear pressure compared to intravenous anesthetic agents. Despite numerous studies comparing the effects of inhalation agents on the middle ear pressure, this is the first clinical trial in which end tidal carbon dioxide and effects of sevoflurane and desflurane, along with other anesthetic analgesic agents used, on the middle ear pressure were compared. Our purpose in this study was to investigate the effect of sevoflurane and desflurane, inhalation agents used in patients who do not have any ear pathology and undergo non-ear surgery under general anesthesia, on the middle ear pressure.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- (ASA) II-III physical status
- elective inguinal hernia
- lower extremity surgery
- general anesthesia
- supine position
- nasal septum,
- adenotonsillar hypertrophy,
- perforated tympanic membrane,
- middle ear pathology
- receive medications for middle ear pressure .
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Desfluran 6-9% 1MAC desflurane, Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups. sevoflurane 2%, 1 MAC Sevoflurane Maintenance of anesthesia was provided with 2% sevoflurane in S Group, and 6-9% desflurane in D Group, with 50% air /oxygen mixture and fresh gas flow at 4 l/min in both groups.
- Primary Outcome Measures
Name Time Method Middle ear pressure postoperative 30th minutes Tympanometric measurements were performed and recorded for each ear preoperatively, at intraoperative 5th, 10th and 15th minutes and postoperative 10th and 30th minutes. Normal middle ear pressure ranges between -200 and +200 decapascals (daPa).
Treatment-Related Adverse Events, Ear and labyrinth disorder Assessed by CTCAE v4.0
- Secondary Outcome Measures
Name Time Method