A Better Choice for Patients Undergoing Endovascular Coil Embolization

Phase 4

Completed

• Conditions: Intracranial Aneurysms
• Interventions: Drug: sevoflurane and 1 μg/kg dexmedetomidine; Drug: sevoflurane and 0.5 μg/kg dexmedetomidine

• Registration Number: NCT01722409
• Lead Sponsor: China Medical University, China

Brief Summary

The investigators designed a double-blind, randomized placebo-controlled study to determine the effects of dexmedetomidine on the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-11-03
• Study First Submitted QC: 2012-11-05
• Study First Posted: 2012-11-06
• Study Start: 2012-12
• Status Verified: 2013-10
• Primary Completion: 2015-02
• Study Completion: 2015-02
• Last Update Submitted: 2015-06-23
• Last Update Posted: 2015-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

18-65 years old ASA I or ASA II patients undergoing ECE treatment for intracranial aneurysms were included.

Exclusion Criteria

Patients were excluded based on the following parameters: older than 65 yrs, a history of mental illness, recent use of sedatives or analgesics and with sensation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane and 1 μg/kg dexmedetomidine	sevoflurane and 1 μg/kg dexmedetomidine	After induction of general anesthesia, Group DEX2 received a single dexmedetomidine dose of 1 μg/kg over 10 minutes.
sevoflurane and 0.5 μg/kg dexmedetomidine	sevoflurane and 0.5 μg/kg dexmedetomidine	After induction of general anesthesia, Group DEX1 received a single dexmedetomidine dose of 0.5 μg/kg over 10 minutes.

Primary Outcome Measures

Name	Time	Method
Observing the recovery characteristics of patients who were scheduled to undergo endovascular coil embolization.	At the end of the operation and 24 hours later	The time from termination of the general anesthetic to the time that the patient's eyes opened. Anesthesiologists collected information on emergence agitation, postoperative nausea and vomiting for 24 hours after the surgery.

Trial Locations

Locations (1)

Wen-fei Tan; 🇨🇳 Shenyang, Liaoning, China