Sedation and Pain (The Effect of IV Sedation on Pain Perception)
Overview
- Phase
- Not Applicable
- Intervention
- propofol
- Conditions
- Pain
- Sponsor
- University of Alabama at Birmingham
- Enrollment
- 86
- Locations
- 1
- Primary Endpoint
- Pain Rating Change
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).
Detailed Description
We propose to contrast and compare the effect of propofol and midazolam, two GABA-related sedative drugs, and dexmedetomidine, an alpha-2 adrenergic agonist, on pain perception in human volunteers by asking a participant to rate their pain and by evaluating a subject's brain activation using fMRI.
Investigators
Michael Froelich
M.D.
University of Alabama at Birmingham
Eligibility Criteria
Inclusion Criteria
- •Healthy subjects
- •19 years or older able to follow study instructions
Exclusion Criteria
- •Age less than 19 or greater than 40
- •Pregnant female
- •Obesity (BMI \> or =35)
- •Non-English speaking/reading participants
- •Sleep apnea
- •Pulmonary problems such as moderate or severe bronchial asthma
- •Cardiovascular problems such as hypertension
- •History of claustrophobia
- •Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device
- •Presence of an unremoved bullet or shrapnel in the body
Arms & Interventions
Propofol
Administration via an IV
Intervention: propofol
Midazolam
Administration via an IV
Intervention: midazolam
Dexmedetomidine
Administration via an IV
Intervention: dexmedetomidine
Outcomes
Primary Outcomes
Pain Rating Change
Time Frame: Sedation
Mechanical Slide Algometer (www.decisionaidsonline.com), Range: "No Pain Sensation" (1) to " Most Intense Sensation Imaginable" (10) 10 point scale. Change Time Points: Baseline (no sedation), Sedation. Same Day Intervention.