Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis: A Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Change from Baseline in Pain Intensity
研究概览
简要总结
The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA).
Patients who receive a corticosteroid injection into the knee joint as part of their routine medical treatment will be monitored prospectively. The study aims to assess changes in range of motion, functional status, and pain levels before the injection and during the early follow-up period after the procedure. This will help healthcare providers better understand the immediate benefits and functional outcomes of this treatment in youth sports and daily physical activities.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with juvenile idiopathic arthritis (JIA) according to standard criteria (arthritis with onset before the age of 16 years and duration longer than 6 weeks with no other identifiable cause).
- •Having unilateral or bilateral active knee joint arthritis.
- •Undergoing knee intra-articular corticosteroid injection (IACI) for the active knee joint involvement.
- •Provision of written informed consent by both patients and their caregivers.
排除标准
- •Presence of other chronic rheumatological diseases.
- •Initiation or discontinuation of systemic steroids, conventional disease-modifying anti-rheumatic drugs (DMARDs) (e.g., methotrexate, sulfasalazine), or biologic DMARDs (e.g., inhibitors of TNF, IL-1, or IL-6) within the 3 months before knee IACI and during the follow-up period.
- •History of severe adverse reactions to steroids.
- •Presence of neurological diseases.
- •History of lower extremity surgery.
- •Missing data.
结局指标
主要结局
Change from Baseline in Pain Intensity
时间窗: Baseline (T0), 2 weeks (T1), and 2 months (T2) post-injection
Pain intensity assessed at rest and during physical activity using a standard assessment scale.
次要结局
未报告次要终点
研究者
Serdar Arslan
Associate Professor
Necmettin Erbakan University