A Comparative Analysis of Dysphagia Relief with External Beam Radiotherapy versus Brachytherapy with External Beam Conditioning in Advanced Esophageal Cancer

A0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年6月26日

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•Endoscopic and biopsy-proven carcinoma of the esophagus either adenocarcinoma or squamous cell carcinoma
•Patient not suitable for radical treatment either
•Due to poor KPS
•Extent of local disease (Primary Stage T4b)
•Unsuitable for concurrent chemotherapy
•Metastatic disease at presentation
•Lesions of the thoracic esophagus and the abdominal esophagus that do not involve the cardiac of the stomach
•Recent imaging (a computed tomography (CT) of the chest and abdomen or whole body PETCT) not more than 3 months old
•Maximum tumor length not more than 10 cm
•Dysphagia immediately before radiation
•Karnofskys performance score is between 40 and 90 inclusive and at baseline
•Signed informed consent

•Age less than 18
•Expected intraluminal catheter insertion not possible even after conditioning radiotherapy
•Tracheoesophageal fistula or deep mucosal ulceration
•Perforation or massive esophageal bleeding
•Stents in situ (i.e. not removed before the first HDR ILBT)
•Previous thoracic radiation therapy for any cause either EBRT or ILBT
•Evidence of other uncontrolled malignancies or evidence of synchronous head and neck or lung primary cancers (regardless of whether those malignancies could be managed with curative intent)
•Pregnant or lactating patients

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