Short-term palliative radiation for painful irresectable pancreatic cancer (PainPanc): a prospective phase 2 study
- Conditions
- Painful Locally advanced or locally recurrent pancreatic cancer
- Registration Number
- NL-OMON20425
- Lead Sponsor
- Academic Medical CenterMeibergdreef 91105 AZ Amsterdam, the Netherlands
- Brief Summary
van Geenen RC, Keyzer-Dekker CM, van Tienhoven G, Obertop H, Gouma DJ. Pain management of patients with unresectable peripancreatic carcinoma. World J Surg. 2002;26:715-20<br> Ceha HM, van Tienhoven G, Gouma DJ, Veenhof CH, Schneider CJ, Rauws EA, et al. Feasibility and efficacy of high dose conformal radiation for patients with locally advanced pancreatic carcinoma. Cancer. 2000;89:2222-9<br> Morganti AG, Trodella L, Valentini V, Barbi S, Macchia G, Mantini G, et al. Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas. J Palliat Care. 2003;19:258-62
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
1. Pain with a NRS ¡Ý 2 as a result of pancreatic cancer, not sufficiently responding to oral, transdermal pain medication or celiac plexus blockade.
2.Primarily irresectable or locally recurrent pancreatic cancer with or without metastases
1.Resectable or borderline resectable tumors without distant metastases
2.Endocrine pancreatic cancer or suspicion of metastasis in the pancreas
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate whether pain relief is successful 4 weeks after the last radiation (7 weeks after start of treatment) . A short course of radiation (3 x 8 Gy) will be given in patients with painful irresectable pancreatic cancer, primary or recurrent.
- Secondary Outcome Measures
Name Time Method •To determine the effect on pain free interval <br /><br>•To determine the reducing effect on (opiod) pain medication<br /><br>•To evaluate the effect on acute toxicity<br /><br>•To evaluate the correlation of radiation volume with acute toxicity<br /><br>•To evaluate the effect on quality of life <br /><br>•To evaluate the overall survival <br />