Pulmonary Hypertension on Prognosis of Acute Myocardial Infarction Patients With Reduced Left Ventricular Function

Completed

• Conditions: Acute Myocardial Infarction; Pulmonary Hypertension
• Interventions: Other: This was an observational study, and no Intervention was given to the patients.

• Registration Number: NCT06186713
• Lead Sponsor: First Affiliated Hospital Xi'an Jiaotong University

Brief Summary

Pulmonary hypertension (PH) has a negative effect on acute myocardial infarction (AMI) patients and appears to be closely associated with reduced left ventricular function. However, its impact on AMI patients with reduced left ventricular function remains unclear. This retrospective study included AMI patients with reduced left ventricular function to investigate the prognostic value of PH in this specific type of patient. Meanwhile, a nomogram would be established basing on the identified independent risk factors, hoping to provide a novel risk stratification for them.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-30
• Study First Submitted: 2023-07-06
• Primary Completion: 2023-07-31
• Study Completion: 2023-08-01
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-28
• Last Update Submitted: 2023-12-28
• Study First Posted: 2024-01-02
• Last Update Posted: 2024-01-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4784

Inclusion Criteria

• The patients who were hospitalized for AMI with reduced left ventricular function at the First Affiliated Hospital of Jiaotong University from January 2018 to January 2022.

Exclusion Criteria

• Myocardial infarction complicated by cardiac rupture.
• Significant pre-existing heart failure.
• Other comorbidities such as malignancy that may significantly affect prognosis.
• Incomplete clinical data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pulmonary hypertension (PH) group	This was an observational study, and no Intervention was given to the patients.	The PH group comprised of patients with systolic pulmonary artery pressure (sPAP) ≥ 35mmHg measured by echocardiology.
Control group	This was an observational study, and no Intervention was given to the patients.	The control group included patients with systolic pulmonary artery pressure (sPAP) \<35mmHg measured by echocardiology.

Primary Outcome Measures

Name	Time	Method
The incidence of all-cause death	1-year after the AMI.	All-cause death will be determined by clinical records or phone calls with patients and their family.

Trial Locations

Locations (1)

First Affiliated Hospital of Xian Jiaotong University; 🇨🇳 Xi'an, Shaanxi, China