Effect of Preoperative Oral Ketamine in Comparison with Ibuprofen on Postoperative Endodontic Pain

School of Dentistry, Islamic Azad University Khorasgan Branch0 个研究点目标入组 51 人开始时间: 待定最近更新: 2018年2月22日

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•1. Patient elects root canal therapy for pain originating from a first or second mandibular molar. 2. The diagnosis of irreversible pulpitis is confirmed by a chief complaint of spontaneous pain and cold test application causing an elevated and lingering pain response. 3. The patient presented with American Society of Anesthesiologists (ASA) I or II medical history. 4. Patient reads and understands questionnaires. 5. Patient reports spontaneous pain above 3cm on a VAS (0-10 cm) in past 24h. 6. Patient provides informed consent.
•Exclusion criteria: 1. Younger than 18 yr or older than 65 yr. 2. Analgesic taken within the last 8h. 3. History of allergy to NSAIDs, ketamine or local anesthetics. 4. Current use of drugs contraindicated with NSAIDs or ketamine. 5. History of gastrointestinal (GI) disorders, renal or hepatic disease, hemorrhagic disorders, active asthma, poorly controlled diabetes mellitus, cardiovascular disease, increased ICP, intracranial mass lesions, ophthalmologic disorder or psychiatric disease. 6. The patient is pregnant or nursing. 7. Periradicular pathosis, other than a widened periodontal ligament. 8. No vital coronal pulp tissue on access. 9. Occurrence of any mistake during root canal therapy.

发起方

School of Dentistry, Islamic Azad University Khorasgan Branch