NIRS and Doppler to Predict NEC in Risk Neonates
Not Applicable
- Conditions
- Necrotizing Enterolitis
- Registration Number
- NCT01833000
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
The main objective is to evaluate the interest of cerebro-splanchnic oxygenation ratio (CSOR) for early diagnosis of necrotizing enterocolitis (NEC) in neonates with rectal bleeding and/or abdominal distension. CSOR will be determined using near infrared spectroscopy (NIRS).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 69
Inclusion Criteria
- less than 28 days neonates hospitalised in neonatology care unit presenting rectal bledding and/or abdominal distension
- signed authorization by the parents (consent form)
Exclusion Criteria
-
- cutaneous lesions in the regions of monitoring
- emergency for NEC
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Cerebro-splanchnic oxygenation ratio up to 48h NIRS assessment
- Secondary Outcome Measures
Name Time Method Mesenteric Doppler flow up to 48h
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link splanchnic hypoxia to NEC progression in preterm infants?
How does NIRS-based CSOR monitoring compare to abdominal X-ray for early NEC detection in neonates?
What specific biomarkers correlate with splanchnic oxygenation changes in NEC risk neonates using Doppler and NIRS?
What are the potential adverse events associated with cerebral and splanchnic NIRS monitoring in neonatal intensive care?
How do mesenteric Doppler parameters complement NIRS in predicting NEC outcomes compared to standard clinical assessments?
Trial Locations
- Locations (1)
University Hospital of Montpellier
🇫🇷Montpellier, France
University Hospital of Montpellier🇫🇷Montpellier, FranceGilles Cambonie, MD,PhDContactg-cambonie@chu-montpellier.frclaire chauveton, pharmDContact+33467330924c-chauveton@chu-montpellier.frgilles Cambonie, MD,PHDPrincipal Investigator