Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases

National Institute of Mental Health and Neuro Sciences, India1 site in 1 country25 target enrollmentDecember 2016

ConditionsSubarachnoid Hemorrhage, Aneurysmal

DrugsNimodipine

Overview

Phase: N/A
Intervention: Not specified
Conditions: Subarachnoid Hemorrhage, Aneurysmal
Sponsor: National Institute of Mental Health and Neuro Sciences, India
Enrollment: 25
Locations: 1
Primary Endpoint: Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of cerebral vasospasm.

Registry

clinicaltrials.gov

Start Date

December 2016

End Date

December 2018

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

National Institute of Mental Health and Neuro Sciences, India

Responsible Party

Principal Investigator

Sriganesh Kamath

Associate Professor

National Institute of Mental Health and Neuro Sciences, India

Eligibility Criteria

Inclusion Criteria

•aneurysmal subarachnoid hemorrhage
•potential or actual cerebral vasospasm

Exclusion Criteria

•non-aneurysmal subarachnoid hemorrhage
•outside the 4-21 day window after ictus
•peripheral deoxygenation
•contraindication for nimodipine administration

Outcomes

Primary Outcomes

Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine

Time Frame: Change from baseline cerebral oxygen saturation at 30 minutes after administration of nimodipine

Secondary Outcomes

Change in the cardiac output measured using near NICOM technology after administration of nimodipine(Change from baseline cardiac output at 30 and 240 minutes after administration of nimodipine)
Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine(Change from baseline cerebral oxygen saturation at 240 minutes after administration of nimodipine)