Noninvasive Assessment of Cerebral Oxygenation and Cardiac Function in Patients With Neurovascular Diseases
Completed
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal
- Registration Number
- NCT02991157
- Lead Sponsor
- National Institute of Mental Health and Neuro Sciences, India
- Brief Summary
This prospective observational study will assess the regional cerebral oxygen saturation and cardiac output non-invasively in patients with subarachnoid hemorrhage during nimodipine administration for the prevention/management of cerebral vasospasm.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- aneurysmal subarachnoid hemorrhage
- potential or actual cerebral vasospasm
Exclusion Criteria
- non-aneurysmal subarachnoid hemorrhage
- outside the 4-21 day window after ictus
- peripheral deoxygenation
- contraindication for nimodipine administration
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine Change from baseline cerebral oxygen saturation at 30 minutes after administration of nimodipine
- Secondary Outcome Measures
Name Time Method Change in the cardiac output measured using near NICOM technology after administration of nimodipine Change from baseline cardiac output at 30 and 240 minutes after administration of nimodipine unit of measurement will be L/min
Change in the cerebral oxygen saturation percentage measured using near infrared spectroscopy technology after administration of nimodipine Change from baseline cerebral oxygen saturation at 240 minutes after administration of nimodipine
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie nimodipine's effect on cerebral vasospasm in subarachnoid hemorrhage patients?
How does noninvasive cerebral oxygen saturation monitoring compare to standard invasive techniques in neurovascular disease management?
What biomarkers correlate with improved cerebral oxygenation outcomes during nimodipine treatment in aneurysmal subarachnoid hemorrhage?
Are there specific adverse events associated with prolonged nimodipine use in neurovascular disease patients and how are they managed?
What combination therapies show synergistic effects with nimodipine for preventing cerebral vasospasm in subarachnoid hemorrhage?
Trial Locations
- Locations (1)
NIMHANS
🇮🇳Bengaluru, India
NIMHANS🇮🇳Bengaluru, India