The Effect of Cerebral Oxymetry in Determining Neurological Outcome in Patients Treated With Therapeutic Hypothermia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypoxic-Ischemic Encephalopathy
- Sponsor
- Tepecik Training and Research Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Measure of cerebral oximetry
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study is designed to assess the effect of cerebral oxygen saturation as an early predictor of neurological outcomes in patients undergoing therapeutic hypothermia after cardiac arrest
Detailed Description
Our study is planned as a prospective observational study. Patients undergoing therapeutic hypothermia in our intensive care unit after cardiac arrest will be enrolled. Each patient's cerebral oxygenation will be monitored with near-infrared spectroscopy (NIRS) in every 6 hours during our 24 hour lasting hypothermia period. Afterwards, patients will be monitorised in every 6 hours during the first day of hypothermia and than the mean values of daily cerebral oxygen values will be noted in the third, fourth and fifth days of nomothermia. Regional oxygen saturation (rSO2) will be noted from left and right probes. Full Outline of Unresponsiveness (FOUR) Score, Glasgow Coma Score (GCS) and cerebral performance category scale (CPC) will be noted at the beginning of therapeutic hypothermia and each day during normothermia, day 21 and the day of discharge from ICU.
Investigators
Aykut Saritas
principal investigator
Tepecik Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients at least 18 years old
- •Patients undergoing therapeutic hypothermia
Exclusion Criteria
- •Patients under 18 years
- •Patients unsuitable for therapeutic hypothermia
Outcomes
Primary Outcomes
Measure of cerebral oximetry
Time Frame: 8 times during the first 48 hours of hospitalization
During the first 48 hours of hospitalization, we will collect the cerebral oximetry values in the two cerebral. hemispheres.
Secondary Outcomes
- The cerebral oximetry values (average of the two hemispheres) will be compared between patients with good and poor neurological outcome according with CPC score(Participants will be followed for 8 times during the first 48 hours of hospitalization, the third day, fourth day and fifth day and the duration of hospital stay, an expected average of 2-4 weeks and a 12 month follow up will be performed)