The effects of vaginal estrogen with probiotics on vaginal microbiota in patients with genitourinary syndrome of menopause
Phase 4
- Conditions
- Postmenopausal women presenting with genotourinary syndrome of menopausevaginal microbiota,genitourinary syndrome of menopuase,vaginal estrogen,probiotic
- Registration Number
- TCTR20200723003
- Lead Sponsor
- Ratchadapiseksompoch fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Natural postmenopause women (more than 12 months of amenorrheic period without other related organic pathologies)
2. Age 45-75 years
3. Women presenting with at least one clinical symptom of genitourinary syndrome of menopause(vaginal dryness, dyspareunia, itching, irritation)
Exclusion Criteria
1. Receive treatment with vaginal moisturizers, vaginal lubricant, vaginal laser, systemic or local estrogens within 90 days before recruitment
2. Pelvic organ prolapse stage 3 or higher
3. BMI of more than 35 kg/m2
4. Vaginal infection within 30 days
5. Any type of vaginal surgery within 90 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Types and quantities of bacteria before and after estrogen and probiotic treatment 12 weeks Next generation (16sRNA) method
- Secondary Outcome Measures
Name Time Method Types and quantities of bacteria in postmenopausal women with genitourinary syndrome of menopause 12 weeks Next generation (16sRNA) method