Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Texas A&M University
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Primary: Strength and muscle gain (DEXA)
Study Overview
Brief Summary
The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.
Detailed Description
The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy.
The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to 69 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •men and women aged 50-69
- •able to perform exercise testing and training
Exclusion Criteria
- •blood pressure > 160/100
- •cardiac arrhythmias
- •aortic aneurysm
- •kidney disease
- •lung disease
- •total cholesterol > 240 mg/dl or < 160 mg/dl
- •current use of cholesterol lowering medications
- •actively participating in >1 hour per week of resistance training
Arms & Interventions
Placebo
< 200 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Resistance Training (Behavioral)
Placebo
< 200 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Sedentary (Behavioral)
Average intake
400 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Resistance Training (Behavioral)
Average intake
400 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Sedentary (Behavioral)
High intake
800 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Resistance Training (Behavioral)
High intake
800 mg/day dietary cholesterol, resistance training, sedentary
Intervention: Sedentary (Behavioral)
Outcomes
Primary Outcomes
Primary: Strength and muscle gain (DEXA)
Time Frame: after 12 weeks of resistance training
Secondary Outcomes
- Secondary: Blood lipids, inflammatory markers, blood pressure(after 12 weeks of resistance training)
Investigators
Steven E.Riechman, PhD, MPH
Associate Professor
Texas A&M University