The Effects of Dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change of cardiac troponin I at preoperative, postoperative，and 24 hours after surgery.
研究概览
简要总结
The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.
详细描述
Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing off - pump coronary artery bypass grafting
- •ASA physical status III-IV
- •Aged 40-70 years
- •NYHA physical status II-III
排除标准
- •Bradycardia
- •Atrioventricular block
- •Echocardiography suggested:LVEF <40%, LVED>65mm
- •Allergic to the drugs
研究组 & 干预措施
Group dexmedetomidine
20 eligible patients are received 0.5ug/kg dexmedetomidine intravenously 15 minutes before surgery
干预措施: dexmedetomidine (Drug)
Group control
20 eligible patients are received equal volumes normal saline intravenously 15 minutes before surgery
干预措施: normal saline (Other)
结局指标
主要结局
Change of cardiac troponin I at preoperative, postoperative，and 24 hours after surgery.
时间窗: At preoperative, postoperative，and 24 hours after surgery.
Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the cTnI，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
Change of Glycogen Phosphorylase Isoenzyme BB at preoperative, postoperative，and 24 hours after surgery.
时间窗: At preoperative, postoperative，and 24 hours after surgery.
Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the GP-BB，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
次要结局
未报告次要终点