The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

Not Applicable

• Conditions: Coronary Artery Bypass, Off-Pump
• Interventions: Drug: dexmedetomidine; Other: normal saline

• Registration Number: NCT03163693
• Lead Sponsor: General Hospital of Ningxia Medical University

Brief Summary

The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Detailed Description

Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2016-02
• Status Verified: 2017-05
• Primary Completion: 2017-05
• Study Completion: 2017-05
• Study First Submitted: 2017-05-15
• Study First Submitted QC: 2017-05-20
• Last Update Submitted: 2017-05-20
• Study First Posted: 2017-05-23
• Last Update Posted: 2017-05-23

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients undergoing off - pump coronary artery bypass grafting
• ASA physical status III-IV
• Aged 40-70 years
• NYHA physical status II-III

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Exclusion Criteria

• Bradycardia
• Atrioventricular block
• Echocardiography suggested:LVEF <40%, LVED>65mm
• Allergic to the drugs

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group dexmedetomidine	dexmedetomidine	20 eligible patients are received 0.5ug/kg dexmedetomidine intravenously 15 minutes before surgery
Group control	normal saline	20 eligible patients are received equal volumes normal saline intravenously 15 minutes before surgery

Primary Outcome Measures

Name	Time	Method
Change of cardiac troponin I at preoperative, postoperative，and 24 hours after surgery.	At preoperative, postoperative，and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the cTnI，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
Change of Glycogen Phosphorylase Isoenzyme BB at preoperative, postoperative，and 24 hours after surgery.	At preoperative, postoperative，and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the GP-BB，which were analyzed by using enzyme linked immunosorbent assay (ELISA).

Trial Locations

Locations (1)

General Hospital of Ningxia Medical University; 🇨🇳 Yinchuan, Ningxia, China