Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The incidence of cardiac complications
研究概览
简要总结
The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation
详细描述
Liver transplantation surgery may lead to myocardial injury. Dexmedetomidine, a highly specific α2-adrenoeptor agonist, has sedative and analgesic properties without significant respiratory depression at the clinically approved dosage. Some investigations indicated that dexmedetomidine was able to protect the myocardium via improving the activity of Na+-K+-adenosine triphosphate enzyme and Ca2+-adenosine triphosphate, alleviating inflammation reaction and avoiding Ca2+ overload. However, the effect and the mechanism of dexmedetomidine on myocardial injury during liver transplantation remain unclear.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •End stage liver disease scheduled for liver transplantation in Tianjin First Center Hospital
排除标准
- •Pre-existing respiratory failure,renal failure,hepatic encephalopathy
研究组 & 干预措施
Dexmedetomidine Group
Dexmedetomidine infusion:loading 0.5ug/kg for 10min, then 0.5 ug/kg/h until the end of operation.
干预措施: Dexmedetomidine (Drug)
Normal saline Group
Equal volume normal saline substitute for dexmedetomidine
干预措施: Normal saline (Drug)
结局指标
主要结局
The incidence of cardiac complications
时间窗: from anesthesia induction to 24 hours after operation
Peri-operative mortality
时间窗: through study completion, an average of 5 weeks
次要结局
- Evidences of Clinically Definite Myocardial Injury Confirmed by Electrochemiluminescence(before skin incision, 0.5 hour min after anhepatic, 2 hours of neohepatic stage,the end of surgery,24 hours after operation)
研究者
Wenli Yu
Wenli Yu,PhD ,Department of Anesthesiology,Tianjin First Center Hospital
Tianjin First Central Hospital