Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation

Not Applicable

• Conditions: Evidence of Liver Transplantation; Myocardial Injury
• Interventions: Drug: Dexmedetomidine; Drug: Normal saline

• Registration Number: NCT03013634
• Lead Sponsor: Tianjin First Central Hospital

Brief Summary

The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation

Detailed Description

Liver transplantation surgery may lead to myocardial injury. Dexmedetomidine, a highly specific α2-adrenoeptor agonist, has sedative and analgesic properties without significant respiratory depression at the clinically approved dosage. Some investigations indicated that dexmedetomidine was able to protect the myocardium via improving the activity of Na+-K+-adenosine triphosphate enzyme and Ca2+-adenosine triphosphate, alleviating inflammation reaction and avoiding Ca2+ overload. However, the effect and the mechanism of dexmedetomidine on myocardial injury during liver transplantation remain unclear.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2016-10
• Study First Submitted: 2016-12-22
• Status Verified: 2017-01
• Study First Submitted QC: 2017-01-04
• Last Update Submitted: 2017-01-04
• Study First Posted: 2017-01-06
• Last Update Posted: 2017-01-06
• Primary Completion: 2017-10
• Study Completion: 2017-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• End stage liver disease scheduled for liver transplantation in Tianjin First Center Hospital

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Exclusion Criteria

• Pre-existing respiratory failure,renal failure,hepatic encephalopathy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine Group	Dexmedetomidine	Dexmedetomidine infusion:loading 0.5ug/kg for 10min, then 0.5 ug/kg/h until the end of operation.
Normal saline Group	Normal saline	Equal volume normal saline substitute for dexmedetomidine

Primary Outcome Measures

Name	Time	Method
The incidence of cardiac complications	from anesthesia induction to 24 hours after operation
Peri-operative mortality	through study completion, an average of 5 weeks

Secondary Outcome Measures

Name	Time	Method
Evidences of Clinically Definite Myocardial Injury Confirmed by Electrochemiluminescence	before skin incision, 0.5 hour min after anhepatic, 2 hours of neohepatic stage,the end of surgery,24 hours after operation	myohemoglobin,creatine kinase isoenzyme,cardiac troponinⅠ,Heart-type fatty acid-binding protein

Trial Locations

Locations (1)

No.24 Fukang Road,Nankai District; 🇨🇳 Tianjin, Tianjin, China