Microglial Cells Activation Imaging Using PET-CT With 18F-DPA714
- Conditions
- Microglial Cells Activation Imaging
- Registration Number
- NCT04171882
- Lead Sponsor
- Weibing Miao, PhD
- Brief Summary
There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in brain injury and degeneration. It is considered that microglial activation would be part of self-propelling cycle of neuroinflammation that fuels Neurologic deterioration. It is however hard to evidence microglial activation in vivo: first, the investigators need very high-resolution imaging tools and then, the only ligand available to date, 11C-PK11195, has a low sensitivity and specificity and provided heterogeneous results. 18F-DPA-714 is a new PET ligand which labels microglial cells. The investigators aim to explore the clinical feasibility used PET-CT with 18F-DPA714 to monitor microglial cells activation of brain in several different disease. This study might reveal significant neuroinflammatory process in the brain. The results of this study might provide a new biomarker of disease pathological progression and help as identifying subjects who might most benefit from a specific anti-inflammatory drug.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 500
- Age > 18 years
- Positron emission tomography scans were acquired more than twice
- Written informed consent was provided by the patients and their health care proxies -
- Contraindication for PET examination
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Standardized Uptake Value (SUV) 2 years Measures of specific binding of 18F-DPA-714 measures of specific binding of the tracer
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Miu weibing
🇨🇳Fuzhou, China
Yao shaobo
🇨🇳Tianjin, China
Miu weibing🇨🇳Fuzhou, ChinaYing Fu, PhDContactfuying1995@163.com