Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- 18F-MK6240 Standardized Uptake Value Ratio
研究概览
简要总结
The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease and/or other related dementias to participate. This includes patients with:
- Mild Cognitive Impairment
- Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties
- Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties
- Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties
- The investigators are also enrolling older adults with normal visual, language, and memory function.
详细描述
This study is being done to learn about inflammation in Alzheimer's disease so that the investigators can find out new ways to treat patients with this disease. Because Alzheimer's disease usually causes slow changes to the brain over time, in this study the investigators are going to perform different tests and then repeat some of them two years later.
Inflammation can be measured using a type of brain scan called a positron emission tomography (PET) scan. A PET scan uses very small amounts of a radioactive drug that is injected into a vein to create a special picture of the brain. The inflammation PET scan uses a drug called ER176. ER176 is an experimental drug but has been used in several human studies before. Once in the body, ER176 sticks to areas with lots of inflammation, and the PET scan allows us to see these areas.
Inflammation can also be measured by looking at certain proteins in the spinal fluid. In order to measure these proteins in the spinal fluid, the investigators need to perform a lumbar puncture (spinal tap). Certain genes that inherited from parents influence the amount of inflammation in the body. The investigators can study how genes affect inflammation in Alzheimer's disease by looking doing genetic tests on blood that collected from the vein.
The investigators can study how genes affect inflammation in Alzheimer's disease by doing genetic tests on blood. The investigators will also be testing blood for severe acute respiratory syndrome (SARS)- CoV-2 (the virus that causes COVID-19) antibodies. The investigators want to see if exposure to the virus that causes COVID-19 changes the amount of inflammation in the brain or not.
Along with inflammation, Alzheimer's disease is also associated with the build up of the proteins amyloid and tau in the brain. The investigators can measure these proteins using PET scans. The amyloid PET scan uses a drug called florbetaben that has been approved by the FDA to help diagnose Alzheimer's disease. The tau PET scan uses a drug called MK-6240. Like ER176, MK-6240 is experimental but has been used in several human studies before.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50 and over at time of screening.
- •At screening, must have no cognitive impairment, or meet criteria for amnestic Alzheimer's disease, posterior cortical atrophy, or logopenic variant primary progressive aphasia. Diagnoses will be made based on history, exam, neuropsychological testing, brain MRI, and consensus diagnosis.
- •Patients must have Clinical Dementia Rating scale score of 0.5 or 1 at enrollment. Controls must have Clinical Dementia Rating scale score of 0 at enrollment.
- •Subjects unable to provide informed consent must have a surrogate decision maker.
- •Written and oral fluency in English or Spanish.
- •Able to participate in all scheduled evaluations and to complete all required tests and procedures.
- •In the opinion of the PI, the subject must be considered likely to comply with the study protocol and to have a high probability of completing the study.
排除标准
- •Past or present history of a brain disorder other than Alzheimer's disease (including presence of cortical infarct on MRI even in absence of clinical stroke).
- •Serious medical conditions, which make study procedures of the current study unsafe. Such serious medical conditions include uncontrolled epilepsy and multiple serious injuries.
- •Contraindication to MRI scanning.
- •Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.).
- •Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits.
- •Exact medication exclusions are up to the discretion of the PI in consultation with the MD liaison.
研究组 & 干预措施
Cognitive impairment
- Mild Cognitive Impairment
- Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties
- Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties
- Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties
干预措施: 18F-MK6240 (Drug)
Cognitive impairment
- Mild Cognitive Impairment
- Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties
- Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties
- Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties
干预措施: 18F-Florbetaben (Drug)
Cognitive impairment
- Mild Cognitive Impairment
- Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties
- Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties
- Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties
干预措施: 11C-ER176 (Drug)
No cognitive impairment
Healthy controls
干预措施: 11C-ER176 (Drug)
Cognitive impairment
- Mild Cognitive Impairment
- Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties
- Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties
- Amnestic Alzheimer's disease - a "typical" version of Alzheimer's disease with memory difficulties
干预措施: Lumbar Puncture (Procedure)
No cognitive impairment
Healthy controls
干预措施: 18F-MK6240 (Drug)
No cognitive impairment
Healthy controls
干预措施: 18F-Florbetaben (Drug)
No cognitive impairment
Healthy controls
干预措施: Lumbar Puncture (Procedure)
结局指标
主要结局
18F-MK6240 Standardized Uptake Value Ratio
时间窗: Up to 24 months
The standardize uptake value ratio is the concentration of radioactivity measured from the 18F-MK6240 PET scan in the cortex compared to the uptake in the cerebellum (pseudo-reference region).
11C-ER176 Standardized Uptake Value Ratio
时间窗: Up to 24 months
The standardize uptake value ratio is the concentration of radioactivity measured from the 11C-ER176 PET scan in the cortex compared to the uptake in the cerebellum (pseudo-reference region).
次要结局
未报告次要终点
研究者
Patrick Lao
Associate Professor of Neurology
Columbia University