Blood Purification Therapy With Dual-cannula in Jugular-femoral Venous

Not Applicable

Not yet recruiting

• Conditions: Vena Cava Disconnection; Blood Purification; Dual-cannula
• Interventions: Device: Hemodialysis Catheter

• Registration Number: NCT05510713
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

Acute kidney failure (AKI) is one of the most important causes of morbidity and mortality for critical ill patients. The use of blood purification treatment such as renal replacement therapy (CRRT) and plasma exchange has gradually developed into an effective treatment. However, the efficiency of blood purification may be affected by the recirculation of dual-lumen venous catheter for some special patients including patients with vena cava reflux disorder from massive occupations or ascites. For extreme cases like patients with vena cava disconnection or severe obstruction, the traditional blood purification treatment cannot work effectively. Thus, we used the dual-cannula in jugular-femoral venous blood purification therapy in the following two patients and found that it can improve the perfusion of systemic circulation and the prognosis of patients

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-18
• Study First Submitted QC: 2022-08-19
• Last Update Submitted: 2022-08-19
• Study First Posted: 2022-08-22
• Last Update Posted: 2022-08-22
• Study Start: 2022-09-01
• Primary Completion: 2024-09-01
• Study Completion: 2024-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• 1. patients requiring haemodilution therapy for various reasons (acute renal failure, acute liver failure, etc.)
• 2. presence of superior vena cava and/or inferior vena cava reflux disorders
• 3. age greater than 18 years

Exclusion Criteria

• 1. Inability to establish suitable vascular access
• 2. Pregnant women
• 3. Not agreeing to active life support treatment
• 4. Severe active bleeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
intervention group	Hemodialysis Catheter	we used the dual-cannula in jugular-femoral venous blood purification therapy in the following patients with vena cava disconnection or severe obstruction

Primary Outcome Measures

Name	Time	Method
vasoactive drugs	144 hours after dual-cannula in jugular-femoral venous	doses of vasoactive drugs
ICU mortality	28-day ICU mortality	Measurement of ICU mortality

Secondary Outcome Measures

Name	Time	Method
Cytokine	24hous after dual-cannula in jugular-femoral venous	Checking cytokine levels by laboratory