Efficacy of the combination of low-dose dexmedetomidine and esketamine in cesarean section surgery
Phase 4
- Conditions
- Cesarean section
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
- Pregnant women over 18 years old<br>2. Full-term singleton pregnancy<br>3. Planned cesarean section under spinal anesthesia<br>4. Agree to participate in this study and sign the informed consent form
Exclusion Criteria
- BMI>27 kg/m^2<br>2. Previous mental disease, central nervous system disease, liver and kidney dysfunction, cardiopulmonary dysfunction, diabetes, or ASA>Grade III<br>3. Serious obstetric complications such as preeclampsia and eclampsia, gestational hypertension, placenta previa or placental abruption<br>4. Stillbirth or neonatal malformation<br>5. Contraindications for spinal anesthesia, including coagulation dysfunction, anticoagulant therapy, severe hypovolemia or hemodynamic instability<br>6. Unable to cooperate with researchers for any reason, such as hearing or visual impairments, language comprehension difficulties, etc<br>7. Known history of allergies and contraindications to the investigational drug<br>8. Heart rate below 50 beats per minute, presence of abnormal cardiac conduction or rhythm, such as sick sinus syndrome and preoperative hypotension (defined as systolic blood pressure<90 mm Hg)
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Neuropsychiatric symptoms associated with esketamine;
- Secondary Outcome Measures
Name Time Method Incidence of intraoperative adverse events;Intraoperative maternal satisfaction score;Additional postoperative analgesics;Postoperative pain score;EPDS Rating;Insomnia Severity Index (ISI);Time to first postoperative anal defecation;Postoperative lactation time;Length of postoperative hospitalization;