study of the combination of dexmedetomidine-propofol, dexmedetomidine and propofol for sedatio

Phase 3

Recruiting

Conditions: eed for sedation during mechanical ventilation.

Registration Number: IRCT20160307026950N54

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Age over 18 years and under 70 mechanical ventilation hospitalized in the intensive care unit, Glasgow coma number is less than 9.

Exclusion Criteria

Patients with contraindications to dexmedetomidine and propofol
Patients with serious mental disorders and dementia
People with acute infectious diseases or severe underlying diseases including liver dysfunction, cardiovascular disorders including heart block, heart rate = 60, heart failure with ejection fraction = 30%, diabetes or severe blood pressure (120/180)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sedation rate of patients. Timepoint: At the base time (before the start of the intervention) and then every 24 hours. Method of measurement: The level of patient sedation will be evaluated using the Ramsay criterion, whose validity and reliability have been confirmed by a recent study.

Secondary Outcome Measures

Name	Time	Method
Mean arterial pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: barometer.;Heart Rate. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: ECG.;Arterial blood oxygen saturation. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: pulse oximeter.;Blood pressure. Timepoint: Baseline time (before the start of the intervention) then every 6 hours. Method of measurement: Barometer.